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KMID : 0939920150470040823
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대한암학회지
2015 Volume.47 No. 4 p.823 ~ p.833
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APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer
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Shin Ju-Hyun
Choi Sung-A
Lee Yu-Ran
Park Myoung-Soo
Na Yong-Gil
Kaikobad Irani
Lee Sang-Do
Park Jin-Bong
Kim Jin-Man
Lim Jae-Sung
Jeon Byeong-Hwa
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Abstract
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Purpose: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer.
Materials and Methods: Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1.
Results: Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548±0.333 ng/100 μL [n=51] for bladder cancer vs. 1.547±0.319 ng/100 μL [n=55] for the control group), with a sensitivity and specificity of 93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage, grade, muscle invasion, and recurrence.
Conclusion: Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
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KEYWORD
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Apurinic/apyrimidinic endonuclease 1/redox factor-1, Urinary bladder neoplasms, Biological markers, Enzyme-linked immunosorbent assay
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